rsi i have been misunderstanding you ( ithink) it looks as though you have a header system as i do? i am talking about when there is only one supply line that goes to a heat exchanger (say in the furnace) and then out to a domestic plate exchanger, and then maybe to a dryer exchanger. what i am saying is the last exchanger will be recieving only warm water if it is the last in the long line, and all were using heat at the same time.
and i have myself 2 rads on 1/2 inch pex and the hot water tank for domestic on 3/4 copper that are always wide open (no valves) that move water always. the only things on zone valves are my heat plenum (because my in ground furnace is designed to run the furnace blower 24/7 in low speed ((and this speed heats my house with the OWB)) and also my floor heat is of course on a zone valve.
i am not sure how much heat loss is in the water but if you look at your chart and say (for what you might be able to figure easily) youtook 10,000 btu out of your 180 degree water as it passed thorugh your HE, what would the temp of the water be leaving it? now if that water went to the next HE and it was not 180 degrees it could not get the full 10,000 btu out of it becasue the chart is designed for 180 degree starting water temp. then when the water left the second HE it would be cooler yet and when it reached the 3rd HE in the line, this HE would not be able to get as many btu as the second one. that is why i dont like a one pipe system.
i think i read a chart that said 180 degree water can deliver 100,000 btu per hour at 10 gpm but as you cool the water delivery the btu per hour drops quickly. perhaps it is not enough to make a difference on a normal winter day but on those cold nights when things are working hard the last rad in the single line could very well (only in my opinion) not be able to meet the heat loss of the room?