I run water thru the main loop (aka thru boiler and into structure) then using w2w fphe. This means I can then run a pressurized system in the house/garage/outbuilding and use glycol.
NOTE: Do not use RV antifreeze, in place of a glycol that is formulated for use in hydronic heating and cooling systems, like Cryo-tek -100. Cryotek is not the only brand out there, just happens to be the one readily available in my area. These types of glycols are designed with additives so that they are pumpable down to temperatures below 32f/0c & do not react with any of the rubber seals/gaskets. Also you have to be careful, there are different types of glycols (propylene, ethylene and methanol) out there and they are not all recommended for contact with PEX, contact supplier about acceptable glycols and mixes (generally no greater than 50/50, by volume)
P.S. If I would have mixed by entire system to 50/50, CB eClassic 2400 and all systems (total of 400 gallons, so about 200 gallons of glycol); would have cost in the area of $4k-$5k. Plus every year I get to check the glycol to make sure it does not go bad, read about glycol "souring", aka going bad from overheating or boiling the glycol mix.