350' loop is alot of pipe, and depending on what your velocity/GPMs are your head pressure could be quite high.
If you are running 1" PEX @ 2ft/sec (or about 3.5 gpm) head pressure is about 2 feet of head/100' -> in your 350' loop, about 7' of head
Now if you are running 1" PEX @ 8ft/sec (or about 14 gpm) head pressure is about 22 feet of head/100' ->or about 77' of head
***DOES NOT INCLUDE HEAD LOSS FROM HEAT EXCHANGERS (HX)***
...you will want to do the math and figure out what velocity/GPM you need, so you have a delta T of about 20F across your HX