If memory serves, my reading of Central Boiler manual
; again I admit to reading manual - I'm sorry. It is best if you can keep all of your open loop piping below the minimum water level of the OWB; you will lessen the change of getting air bubbles stuck in the lines and vapor locks occuring.
*** If a portion of open loop is above overflow of the OWB and leaks, water level will more than likely drop to lowest open portion of the loop (probably the overflow on the OWB)***
I personally have open loop from OWB (CB eClassis 2400) to mechanical room then Flat plate to closed loop for in slab and under subfloor. Closed loop systems are nice if you want to run a glycol mix (and not have to mix entire water jacket 200+ gallons with $$$/gallon antifreeze) or radiant application where a portion o application is above overflow/high point of open loop OWB. Remember with any HX you incur a penalty in temperature (as in any energy tranfer loss are inevitable) and typically loss of GPM (generally HX have high pressure drops)